Curriculum Vitae for Floyd E. Taub, M.D.
section 2
1982-1984: Head, Pathology Unit, Laboratory of Oral Medicine (Chief: Abner Notkins, M.D.) National Institute of Dental Research, and National Institutes of Health, Bethesda, MD. The unit specialized in the use of human monoclonal antibodies (derived by hybridoma technology and EBV transformation) in pathology and in the study of autoimmunity. Several of these antibodies were evaluated as clinical diagnostic tools for detecting and evaluating cancers. Research and clinical assays of autoimmunity in diabetes were developed.
1981-1982: First Surgical Pathology Fellow at George Washington University (Head, Anatomic Pathology: Steven Silverberg, M.D.). Served as "Attending Pathologist."
1978-1981: Research Associate, National Cancer Institute, Laboratory of Biochemistry (Chiefs: Robert Goldberger, M.D., and Maxine Singer, Ph.D.), Biochemistry of Gene Expression Section (Head: E. Brad Thompson). Studies on the control of glucocorticoid inducible genes. The methods used included recombinant DNA technology, somatic cell hybridizations, enzyme purification, antibody production, and solution and filter hybridization of nucleic acids. This work included differential screening of a rat liver cDNA library to directly identify clones containing glucocorticoid-induced or -repressed RNA sequences.
Developed a unique system using computerized image processing, enhancement, and quantification to evaluate gene expression (Genomics) via solution-solid phase hybridization to each member of a cDNA library. This technology allowed detailed study of gene regulation and isolation of specific recombinant clones. This new system is the nucleic acid counterpart of comparative two-dimensional protein gel electrophoresis.
1976-1978: Autopsy Supervisor, University of Colorado Medical Center. Designed the program and was responsible for supervising the autopsy-related work of up to 12 physicians. Favorable evaluation led to the program's continuation after his tenure at UCMC ended.
Research with Paul Nakane, Ph.D., Pathology Department, University of Colorado Medical Center. Differentiation of pituitary cells following endocrine manipulation in vivo was studied. Techniques used included multiple peroxidase-labeled anti-hormone antibodies and flow microfluorometry.
1974-1976: Research with Terry Johnson, Ph.D., Department of Microbiology, Northwestern University Medical School. (Dr. Johnson is now Professor/Director of the Division of Biology, Kansas State University.) A model system for pediatric brain damage in the genetic disease phenylketonuria (PKU) was examined. Nucleic acid and protein biochemistry defined the molecular site of inhibition of protein synthesis in immature rat brain following phenylalanine overloading. Based on this work, a new therapeutic approach was devised. This approach was effective in an animal model of PKU.
1971: National Science Foundation Research Participation Program Grantee for work with Aryeh Routtenberg, Ph.D., at Northwestern University Psychology Department. A novel method for determination and documentation of functional relationships between structurally diverse CNS regions was devised.
1968-1969: Research and study under Rulon Rawson, M.D., Vice President and Dean, New Jersey College of Medicine and Dentistry. In vivo studies of induction of red blood cell production by erythropoietin (epo) following radiation injury were performed. This work led to a Special Army Science Award. Epo class drugs have a market of over $5 billion and for many years been the best selling biotechnology drugs. The are used to treat fatigue. However unlike the drugs Dr. Taub has recently developed their use is limited to those with anemia. |